Alex and Jo’s wedding day has arrived, but a mishap may keep the pair from walking down the aisle. All of their friends and colleagues gather around for the event, and two of their own say farewell.

One of Grey Sloan Memorial’s own is seriously injured, making the team reflect on what is truly important to them. Meanwhile, Nicole Herman pays a visit to Grey Sloan and talks to Arizona about an exciting opportunity.

Alex and Jo go on a road trip to Iowa to find Alex’s mom, whom he hasn’t heard from in a very long time. Meanwhile, Meredith gives a presentation on her mini-livers project, which attracts a ton of attention; and Jackson works to rebuild the foundation after its reputation is threatened.

On Grey’s Anatomy Season 14 Episode 21, Nurse Olivia shows up with her son, throwing Alex and Jo for a loop, while the hospital brings in crisis management.

During presentations on Grey Sloan Surgical Innovation Prototypes Day, Arizona shares some cookies from an appreciative patient that, unbeknownst to her, contain a special ingredient. Meanwhile, Catherine reveals some shocking details to Jackson about his grandfather’s past; and Jo steps in mid-operation on a major surgery after Bailey and Meredith are down for the count.

An agent from ICE shows up at Grey Sloan in search of an employee who may be working in the U.S. under DACA. Alex’s patient Kimmie wants to leave the hospital to enjoy her final days, but Alex feels differently. Meanwhile, Arizona treats Matthew Taylor’s baby and April wants to do whatever she can to help.

Amelia, Koracick and DeLuca perform a risky, groundbreaking procedure using ultrasound waves to remove a young patient’s brain tumor. Meanwhile, Meredith and Jo work with different polymers to try to salvage their project submission; and Richard’s AA sponsor is admitted to Grey Sloan with a DNR.

April’s crisis of faith is challenged by a patient she treats who is a rabbi, and Meredith treats a patient who is a transplant surgeon from another hospital.

On Grey’s Anatomy Season 14 Episode 16 Maggie and Jackson are enjoying spending time together, but he must turn his concentration toward the groundbreaking vaginoplasty surgery he has scheduled with Catherine and Richard.

Meredith tries to learn more about Marie Cerone’s history with her mother. Meanwhile, Jo is applying for fellowships around the country and it throws Alex for a loop; and Tom Koracick helps April acknowledge her crisis of faith.