In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," four of our favorite Seattle Grace staff members stand outside their place of employment.

In this scene from "Invasion," it appears Izzie wants a piece of some of the new residents. Oh, it's going to get ugly this week, alright.

A photo from the fourth season finale of Grey's Anatomy, "Freedom." Alex Karev and Izzie Stevens are in the heat of a discussion... will the episode end with them getting back together?

So she says. And she's right.

Alex pleads with Izzie to let Denny go.

What a pimp. Look at this guy! Way to go, George!

Isobel "Izzie" Stevens is ready to get it on. In the O.R. And in Denny's room.

Izzie and Alex kiss after exchanging vows in their emotional wedding. The whole gang was on hand to watch the two doctors get married.

Izzie Stevens, M.D.

We can't get enough of these three.

Or at least until two of them hook up and things are weird.

Alex tends to ailing Izzie in an emotional Season Five scene from Grey's Anatomy. These two have become bigger and bigger characters since the series debuted.