We can see why Denny digs her.

Sorry, tasteless joke. Had to be done.

We have no idea what's going on here yet, as this episode hasn't aired at the time we're uploading this picture. But it looks funny!

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Izzie and Mark have a serious conversation in the halls of Seattle Grace.

What happens on this all-new episode of Grey's Anatomy January 21? You be the judget of that.

Alex and Izzie don't know what the best course of action is going forward, and it's hard to blame them.

Miranda barks orders at Izzie, Meredith, Cristina and Alex in this new promotional photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy.

We do heart Izzie in spite of her flaws. Here she is in a photo from the fourth season finale of Grey's Anatomy, "Freedom."

Izzie and Alex got married in May of 2009 near the end of Season 5 of Grey's Anatomy. But life has not gotten any easier since.

That was the climactic scene of the 100th episode of Grey's Anatomy - the surprise nuptials of Alex and Izzie. Meredith and Derek were the ones supposedly getting married this day!

Cristina has Burke's cap!!!

They do their thing, as always! Mark, Izzie and Callie tend to a patient played by guest star Ben Vereen in an early Season Four episode of "Grey's Anatomy."