New intern Sadie (Melissa George) and Meredith (Ellen Pompeo) are said to have some sort of sexual history. OMG. Could it be true?

Who knows what's up with Alex and Aaron Karev, but it's clear there is bad blood, or at least animosity, and we will find out more soon enough.

We've missed her. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Meredith wears her familiar, concerned expression. We hope it's not for the worst ...

A shot from the February 10, 2011 episode of Grey's Anatomy. This is not going to be a good week for the Greys.

At least Izzie seems to be. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Stevens and other doctors at Seattle Grace stand outside. What will happen next?!

In "Here Comes the Flood," from the fifth season of Grey's Anatomy, Meredith waits outside. Will she get Alex and Izzie to move out?

Sorry, Mark, Meredith's having none of it.

What has changed in the alternate world of Grey's Anatomy? Cristina's hair and Mer's demeanor, for starters.

Meredith, Isobel and Dr. Yang look on.

Meredith mulls over a question

Doesn't quite roll off the tongue like yin & yang, but what are you gonna do.

Yang can't handle being free again.