Meredith smiles here at Amelia. It's a scene from the Grey's Anatomy episode "We Are Never Getting Back Together."

April's wedding begins on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

It's Meredith's turn to walk down the aisle at April's wedding on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

Cristina eyes Meredith in this scene from "You've Got To Hide Your Love Away." After all these years, we still adore these two.

Meredith and Cristina look on skeptically in this photo from the Grey's Anatomy episode "You've Got To Hide Your Love Away."

Meredith waves goodbye in this Grey's Anatomy scene. Her person is now gone.

It's Derek vs. Meredith! These two did not end Grey's Anatomy Season 10 on a positive note.

Meredith is serious about finding a new research assistant. "We Gotta Get Out of This Place" is the 16th episode of the show's tenth season.

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Why does Stephanie look so concerned? What did Meredith just say to them on Grey's Anatomy?

A little help here, please? Meredith looks frazzled in this Grey's Anatomy premiere photo.

This situation looks dire. Meredith is tending to a patient on the Season 11 premiere.