Nope, it just doesn't work. Go away Rose! She probably will leave our Der alone... at least that's what Grey's Anatomy spoilers have indicated. She looks to be a factor in this episode #12 of Grey's Anatomy's fourth season, though.
Mark: I don't like her. I'm sorry, but as your friend it's my job to say I don't like Rose. Derek: Why? Mark: You're not even sleeping with her. Derek: You don't like her 'cause she's not sleeping with me? That's a little weird. Mark: It's not weird. Derek: It's a little weird.