Neve Campbell as Der's sister Lizzie in a photo from "Run, Baby, Run," the December 13, 2012 episode of Grey's Anatomy.

Or smiles? We can't really tell. But in this picture from "These Ties That Bind," the eighth episode of Season Five of Grey's Anatomy, Mark looks intrigued by something to say the least.

Cristina reacts after apparently belting a home run. Or at least making some solid contact.

Mer works on her technique in a photo from the January 31, 2013 episode of Grey's Anatomy.

Mer and Callie in a photo from the December 6, 2012 episode of Grey's Anatomy.

Yes. Yes it was. A natural disaster hits in this scene from Grey's Anatomy.

Callie's got the wine out in the April 12, 2012 episode of Grey's Anatomy, "Support System."

Meredith Grey in a photo from the February 11, 2010 episode of Grey's Anatomy. She looks great! No sign that she had a baby at all! Oh wait, that's Ellen Pompeo ...

Six seasons in and Patrick Dempsey hasn't gotten any less McDreamy. We're just saying we love Derek.

Will Meredith pay the price for what she did on the clinical trial?

It's ladies night in Seattle! Here's a picture of Teddy, Arizona and Callie in the April 12, 2012 episode of Grey's Anatomy, "Support System."

This is the episode in which Derek Shepherd allegedly quits his job at Seattle Grace. When, if ever, will he be talked out of it?