DeLuca may be wondering what has brought his sister all the way from Italy to GSM because it can't possibly be just to visit her charming brother. Siblings always have ulterior motives. Will he be the person behind his sister making a startling new discovery?
Is Maggie part of the team of doctors helping Megan? It's always good to have a child prodigy on the case. What if she's working with DeLuca's sister instead? That could certainly make things interesting given her history with DeLuca.
How does DeLuca spend a day off? Coming into the hospital anyway. Maybe he wanted to check in on his sister who has mysteriously appeared at GSM with a controversial research trial that will get everyone talking.
Meredith and the others are busy coming up with a new plan to help Megan Hunt, but Amelia busies herself with a complicated new case. Could she be giving everyone the space they need, or is she avoiding Owen because a sibling rising from the dead stirs up feelings?
Things did not end well between Arizona and Eliza in the season finale. Their relationship came to an end just as Eliza's job at GSM came to an end. Either a significant amount of time has passed, or Arizona isn't that torn up about it. Could it have anything to do with her roommate's relative popping up?