Addison, Naomi and Sam rush to Seattle Grace with Archer and reunite with old friends Derek and Mark. Izzie employs her fellow doctors in a medical game. Owen runs into someone from his past.

In “Beat Your Heart Out,” Derek searches for the best way to pop the question to our girl, while Little Grey wants to go public with Big Sloan.

As a patient’s condition becomes more and more dire, Bailey becomes more and more desperate to do something – anything – to save him.

Death row inmate William is still around and he’s shaking things up, while Derek’s mother comes to Seattle Grace and meets Meredith for the first time.

Grey’s Anatomy returns from its holiday hiatus with its 11th episode of Season Five.

Dr. Yang is forced to give up the coveted solo surgery, while sparks between Mark and Lexie possibly heat up.

Why the heck are the interns cutting themselves? And why the heck is Izzie still seeing Denny? And what happens when it all goes wrong?

As if this season weren’t turbulent enough, it’s time for a couple of newcomers – Harriet Dixon and intern Sadie – to make their debuts and shake things up at Seattle Grace.

The sudden revelation that this is Brooke Smith’s (Erica Hahn) last episode has dominated the discussion and speculation of this episode so far.

Empowered by the Chief, Bailey has new responsibility and the new head of trauma – Owen Hunt – is shaking things up at Seattle Grace.