CRISTINA: [to Mer, but everyone hears] "Are you pregnant?"
ADDISON: [to Derek] "An adulterous love child?"
DEREK: "Goes along with an adulterous sociopath."

Meredith: So, I got Alex to cover for me so I can leave right after I round on my patients. 48 uninterrupted hours!
Derek: Yeah yeah... um... you know, maybe this is not a good weekend.
Meredith: What did Lexie say about me?
Derek: She didn't say anything. I did all the talking. Oh, don't blame her.
Meredith: So what, you're friends with my sister now? I mean, you talked to the other Grey about me?
Derek: You know what I talked about with the other Grey? All the things this Grey won't let me say.
Meredith: You can say anything to me.

IZZIE: "You want us to make her seize? How do we make someone have a seizure?"
DEREK: "Get creative. Do some research."
GEORGE: "Well, if all the normal methods have failed then what are we supposed to do-"
DEREK: "Use a strobe light. Get her drunk. Hang her up upside down from the ceiling and hit her with a wiffle ball bat, for all I care. Just make her seize. 'Cause until she seizes, I don't know when to operate, and if I don't know when to operate, I can't get this woman out of my life. And this woman is not how I like to start my mornings."

MEREDITH: "Oh, you have got to be kidding me? Where's George?"
DEREK: "Spent the night at the hospital."
MEREDITH: "And you slept in his bed! All night?"
DEREK: "No, right after you fell asleep."

Derek: It’s a little...
Meredith: It’s not that strange. I mean, I’m trying to figure out how to put her to rest. I can’t shove her in the back of my closet anymore. I have to deal with her. And this is me trying... to evolve. I’m trying here. So, cubby or car?
Derek: You’re asking me if I think you should put your mom’s ashes in your cubby or your car. You don’t think that’s very very strange?
Boy: Are those really your mom’s ashes?
Derek: It’s strange, right? It’s strange.

Mark: Well, you're all set here, I'll leave you to it.
Derek: Thanks.
Mark: Congratulations.
Derek: Thanks.
[phone rings]
Derek: Addison? ... What happened?

Meredith: I'm going to miss you.
Derek: This can work. We can make this work. We will.

Alex: She's like the woman who couldn't remember her husband was dead. We had to keep telling her every 5 minutes.
Derek: It's a perfectly normal post operative haze.
Alex: Or, the bleeding during the procedure blitzed her short term retention. Did you screw up her brain?
Derek: Karev, I'll be back. Try and stay calm. Freaking her out is not gonna help. (Der walks away)
Alex: Wake up.

PRESTON: "I haven't had a tremor."
DEREK: "Wow. That's great to hear."

Richard: Shepherd?
Derek: You're a hard man to track down.
Richard: I'm busy, as you know.
Derek: Yeah, scoping out Mercy West. You planning on jumping ship? 'Cause I assume as a friend you would tell me if there's anything I need to know.
Richard: Those are rumors Derek.
Derek: There are a lot of rumors, and Jennings isn't answering my calls anymore.
Richard: Why are you calling Jennings Derek? I told you I would fill you in when there was something to tell. If you feel the need to go behind my back, at least do...
Derek: Behind your back? Behind your back! I'm the one whose got your back. Don't you forget that.

CRISTINA: "Katie competes in beauty pageants."
DEREK: "I know that, but we have to save her life anyway."

Meredith: Let me finish Derek, I got this.
Derek: Yes you do.

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey