DEREK: "Do you happen to know what time of year neurosurgeons are busiest, Dr. Stevens?"
IZZIE: "There's a particular time of year?"
DEREK: "There's no hard or fast rule, but brain injuries tend to pile up around the holidays. Folks fall off roofs while they string up lights. They go skating for the first time in a decade and break their heads open. Every year people drive through blizzards to get to parties where they kiss germ infected strangers under poisonous mistletoe. Then they get drunk and smash their heads through their windshield on their way home. But there's no hard or fast rule."

RICHARD: "You and I both know she's the best in the field. Bringing Addison out was a business decision. It's nothing personal."
DEREK: "Oh, well, that's a relief. Not personal. It's personal to me!"

ADDISON: "Am I interrupting?"
RICHARD: "You're never interrupting."
DEREK: "She's always interrupting."

DEREK: "Addison, what are you doing here?"
ADDISON: "What are YOU doing here? You left everything -- your house, your wife, your practice. You had a life. Now you have a girlfriend in Seattle. She seems... sweet."

PRESTON: "So what's the story with you and Grey?"
DEREK: [pauses] "I got drunk and she took advantage of me. Or she got drunk and I took advantage of her. Well, either way, we were drunk, definitely, and somebody took advantage. I look at it as my initiation into Seattle. What about you?"
PRESTON: "I don't have a story, I just wanted to hear yours."

DEREK: "Meredith, I understand..."
MEREDITH: "Do you? Somehow I doubt it. Because if you did, you would shut up, turn around and go back inside, because you would realize that I am this close to getting in my car and running you over in the parking lot!"

[to Meredith] "So I go upstairs, preparing myself for what I'm going to see when I walk into my bedroom. I step on a man's jacket that doesn't belong to me. Then everything I know... it just shifts. Because what I know now is that when I go into my bedroom, I'm not just going to see that my wife is cheating on me. I'm going to see that my wife is cheating on me with Mark, who happens to be my best friend."

RICHARD: "You called my wife?"
DEREK: "You called mine!"

ADDISON: "We got successful, you and me. We got busy and we got lazy. We didn't even bother to fight anymore, Derek. Mark was there and I missed you and now I'm sorry. I'm more sorry than you could possibly imagine, but at least I'm talking to you about it."
DEREK: "I'm a sink with an open drain, Addie."

DEREK: "Addison and I are over, Adele."
ADDISON: "Oh, it's not like we're divorced."
DEREK: "We're practically divorced."
ADELE: [to Addison] "You've had counseling?"
DEREK: "We've had adultery. That was enough."

DIVORCE LAWYER PATIENT: "Any of you are looking to get out of a bad marriage?"
GEORGE & IZZIE: [smirking] "No."
DIVORCE LAWYER PATIENT: "Dr. Shepherd?"
DEREK: "Yes. No!"

[to Addison] "There is a land called Passive Agresseva, and you are their queen."

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey