Meredith: He's done this before.
Maggie: What?
Meredith: Moved to a new city, got a new job, ignored his wife's calls, met a girl, fell in love, started over.
Callie: Wait, what are you talking about, "met a girl"?
Meredith: Me. He met me. He left Addison when the marriage got hard, moved to Seattle, met me in a bar. What if he's doing the same thing now?

There’s this thing I used to do when I was a kid to my mom’s VCR. I’d take it apart piece by piece, then put it back together again. But inevitably, there was always a piece or two left over. Something I didn’t quite know what to do with. So, what do you do with that piece? Do you try to fit it back in? Do you try to make it work? Or do you decide you can live without that missing piece?

Meredith: It seems like you came home because you thought you were in trouble.
Derek: I came home because we're on trouble. I came home to work on us. I came home.

Derek: I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it.
Meredith: I can live without you, but I don't want to. I don't ever want to.

Just because we can live without something, it doesn't mean we have to.

Bailey: Grey, look I had to try.
Meredith: For your patient, I know, but now that's dozens of transplant patients that you just screwed out of a chance.

He's different. I don't know how to explain it, but I think he realizes what makes him happy and he's choosing it. And that makes me happy. I think this is his moment.

Amelia: Owen and I are getting to know each other.
Meredith: How well? Pants on or pants off well? Is it just sex, or is there something more?

Bailey: You and Derek went down in a plane, you drowned, he got shot, you gave birth in a power outage...
Meredith: Is this supposed to make me feel better?
Bailey: I'm just saying, you have every reason to be distracted. Every reason to think the sky is falling.

I didn't think I could do it. Part of me thought, what if I had this baby and just die? And then she arrived, and I saw her face, and I saw him in her. She's beautiful.

I came back, but I'm not home. And I really want to be home.

Meredith: I hurt her feelings, and she's mad at me. I forgot I'm supposed to be her sister.
Alex: You're a complete tool sometimes.
Meredith: I've heard.

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey