Sheldon: Amy, there were Chinese food containers ... in the trash can.
Amy: Poor Leonard.

Howard: I feel so stupid. And fat.
Bernadette: That's okay. You still look great to me. In fact, why don't we go in the bedroom and I'll prove it to you?
Howard: Sex? Really? That's just your solution for everything.

Howard: You're full of estrogen and you don't act like that.
Bernadette: That's 'cause I'm a woman. I've had years of practice riding the dragon.

I have to hit the head. That's what us salty seadogs say when we have to go pee-pee.

Leonard

Raj: Why are you on a diet?
Howard: I've put on a couple pounds. I buy these pants in the men's section.
Raj: Well, we've all seen your mom. That Butterball turkey was bound to come home to roost.

Howard: What were they thinking putting Doctor Octopus's mind in Spider-Man's body?
Raj: Well, I've been quite enjoying that. It combines all the superhero fun of Spider-Man with all the body-switching shenanigans of Freaky Friday. Both versions: original and Lohan.
Howard (imitating Raj): "Both versions: original and Lohan."

Don't try to trick me into buying something I don't want. Now, let's talk Aquaman.

Sheldon

Leonard: I didn't tell Sheldon so we could have a few days alone.
Penny: Oh, that is so romantic.
Leonard: Uh, sure, that's why I did it.

I don't know if she's bi-racial, honey. I think she's bi-species. She's half worm, half human.

Crosby

Julia: You know, I've only ever had the one job since grad school. I put all my eggs in one basket, and now that Leon is being vindictive, I'm screwed. And he deserves to be, because I messed up. He has every
right...
Joel: Honey, you didn't screw up, you chose your children over your work.
Julia: Thank you, but that is revisionist, I got overwhelmed and I screwed up.

Joel: I'm just excited about the possibility of working with you.
Pete: Woah - slow down Speed Racer, we're not there yet.

I'm sure you're going to be the best thing that ever happened to me someday, but right now I really hate you.

Crosby