I am fresh out of sympathy for liars who kidnapped my friends and replaced them with killer robots.

Simmons [to Radcliffe]

Simmons: You're not crazy!
Coulson: I live alone and make my own soap.
Simmons: It's quaint. Hipster, even!

Trust is a luxury these days.

Mace

Coulson: Got to say, the whole Rebel Alliance aesthetic is really working for me.
Mace: I'll take that as a compliment. I think.

It's me again. Phil Coulson. I called Hydra on you. My bad.

Coulson [to Simmons]

This reality may be upside down, but Fitz is still Fitz. He's a good person.

Simmons [to Daisy]

Madame Hydra: You'd really do anything for me, wouldn't you?
Fitz: I'd cross the universe for you.

Fitz: Treat this mole like a cancer.
May: I'll cut it out myself

Daisy: Wait, are you still dead?
Simmons: No, I'm feeling much better.

Student: Are Hydra all Nazis?
Simmons: Every last one of them. And don't you let anyone forget it.

Do you have moments where reality isn't quite right? Like your memories don't fit?

Simmons [to Coulson]

You have dreams. This is all so real. So many computational layers.

Simmons

Agents of S.H.I.E.L.D. Season 4 Quotes

Fitz [on Aida]: It has bloody microexpressions!
Dr. Radcliffe: She.

The world knows her as Quake. And Quake is an outlaw who takes out banks and bridges.

Melinda May [on Daisy]