You can't sink, with all that helium in you you'll float away.

Raj [to Sheldon]

We represent the lollipop gang and we want you.

Raj [to Sheldon]

Wolowitz: In romance, like show business, always leave them wanting more.
Leonard: What does that mean?
Penny: He struck out.

Wow. It's like the Ganges on laundry day.

Raj

I never admit defeat. However, on an unrelated topic, I'm never getting out of this bed again.

Sheldon

Katee: Thanks, Howard. Always nice to be part of your masturbatory fantasies.
Wolowitz: Come on, Katee. Don't make it sound so cheap.
Katee: I'm sorry. Fiddling with yourself in the bathtub is a real class act.

Wolowitz [about Bernadette]: She wants a commitment, but I'm not sure if she's my type.
Penny: She agreed to go out with you for free. What more do you need?

My mother is very excited. She's convening her Bible study group to listen in and then pray for my soul.

Sheldon

Wolowitz: Before you and Penny hooked up, did she ask for any sort of commitment?
Leonard: No, she was pretty clear about wanting to keep her options open.

Sheldon: Why do you have the Chinese character for "soup" tattooed on your right buttock?
Penny: It's not "soup," it's "courage."
Sheldon: No it isn't. But I suppose it does take courage to demonstrate that kind of commitment to soup.
Penny: How'd you see it? You said you wouldn't look.
Sheldon: Sorry. As I told you, the hero always peeks.

Leonard: The meteors are so pretty.
Raj: With your American accent, everything you say sounds stupid.

You keep in mind that my sharply-worded comments on yelp.com recently took down a muffin store

Sheldon

The Big Bang Theory Season 3 Quotes

Wolowitz: Sheldon. You remember the first few weeks; we were looking for magnetic monopoles and not finding anything, and you were acting like an obnoxious, giant dictator?
Raj: I thought we were going to be gentle with him.
Wolowitz: That's why I added the "tator"

Wolowitz [after seeing Penny jump Leonard]: Damnit, I should have gone over and said we were back
Raj: Yeah, it was "first come, first serve."