Fitzsimmons go undercover to find a geneticist that worked on humans to make them better than humans could be, improving them with technology, which they believe can help them find a cure for Hive's brainwashing.
Once they track him down, they're put in an uncomfortable situation when he forces them to use the cybernetic eye technology on a live human specimen, the technology they were using to get in to see him.
Coulson and May deal with Daisy's disappearance in their own ways: Coulson is afraid for the daughter he never had, the closest thing to the daughter he's ever had, while May is angry with Coulson for the demands he makes of her as S.H.I.E.L.D.'s deadliest agent.
S.H.I.E.L.D. attempts to track Hive and daisy's trail and get one step ahead of them, but they're always steps behind. Hive planted the Inhuman they were looking to protect, transformed the other than Lincoln teased with powers, and found Fitz and Simmons at the geneticist's lab, before Coulson and his team knew Hive was on their trail.
Hive reveals more of his plan to Daisy as they bond with his parasites in her head, rounding up all the Inhumans she's aware of.