Patrick Dempsey as Derek Shepherd: A Handsome Tribute

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Rest in peace, Derek Shepherd. And best of luck with what comes next, Patrick Dempsey.

1. Rest in Peace, McDreamy

Rest in Peace, McDreamy
The Derek Shepherd smirk will leave on forever and ever in the hearts and minds of Grey's Anatomy fans.

2. Give Me 10!

Give Me 10!
Derek gets the double high-five request in "Readiness is All."

3. Owen and Der

Owen and Der
Derek and Owen in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

4. Derek: Handsome Fella

Derek: Handsome Fella
Derek looking handsome as ever in a photo from "Transplant Wasteland." The episode airs March 14, 2012.

5. Meredith and Derek in Bed

Meredith and Derek in Bed
Meredith and Derek in bed on Grey's Anatomy!

6. Up Top With Derek!

Up Top With Derek!
Derek shares a double high-five in the May 9, 2013 episode of Grey's Anatomy, "Readiness is All."

7. A Confused Couple

A Confused Couple
Wait... huh? Who?!? What?!? Derek and Meredith are a tad taken aback in this Grey's Anatomy scene.

8. Veronica Cartwright on Grey's Anatomy

Veronica Cartwright on Grey's Anatomy
Veronica Cartwright guest stars here on Grey's Anatomy. As you can see, she plays a patient of Derek's.

9. MerDer and Baby

MerDer and Baby
Does it get any sweeter than this? Derek holds his child as Meredith looks on.

10. Derek and the Baby

Derek and the Baby
Derek and the baby in a shot from Grey's Anatomy's third episode of Season 10.

11. Derek vs. Meredith - Grey's Anatomy

Derek vs. Meredith - Grey's Anatomy
It's Derek vs. Meredith! These two did not end Grey's Anatomy Season 10 on a positive note.

12. Derek vs. Amelia - Grey's Anatomy Season 11 Episode 7

Derek vs. Amelia - Grey's Anatomy Season 11 Episode 7
Derek and Amelia are having some issues on Grey's Anatomy. They are not getting along professionally in any way, shape or form.

13. Derek, Meredith and Zola Picture

Derek, Meredith and Zola Picture
Derek, Meredith and Zola in a scene from this week's Grey's Anatomy episode, "This is Why We Fight."

14. Derek, In Thought - Grey's Anatomy Season 11 Episode 7

Derek, In Thought - Grey's Anatomy Season 11 Episode 7
Derek looks on in this scene from Grey's Anatomy Season 11. It's from the episode "Can We Start Again Please?"

15. Derek's Satisfaction

Derek's Satisfaction
Derek looks satisfied with his results on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

16. The Right Results

The Right Results
Did Derek get the results he expected on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

17. Enjoying the Work

Enjoying the Work
Derek looks like he's enjoying his new project on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

18. Derek and Shane

Derek and Shane
Derek and Shane work together on a brain mapping project on Grey's Anatomy. "Map of You" is the sixth episode of the show's tenth season.

19. Ben and Derek

Ben and Derek
Ben and Derek collaborate on a new technique on Grey's Anatomy. "Thriller" is the seventh episode of the show's tenth season.

20. Derek Gets News

Derek Gets News
Derek gets news that could change things on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

21. Dr. & Mrs. Shep

Dr. & Mrs. Shep
Meredith and Derek in a scene from the May 9, 2013 episode of Grey's Anatomy, "Readiness is All."

22. Owen and Derek

Owen and Derek
Derek and Owen in a photo from "Transplant Wasteland." This Grey's Anatomy episode airs March 14, 2013.

23. Derek and Baby

Derek and Baby
Derek had to bring the baby in to work on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

24. Derek Gets An Offer

Derek Gets An Offer
Derek gets an offer that could change everything on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.

25. Smiling Derek

Smiling Derek
It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?

26. Fighting to Save a Life

Fighting to Save a Life
When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"

27. That Handsome Man

That Handsome Man
Dr. Derek Shepherd in "Transplant Wasteland."

28. Meredith & Derek

Meredith & Derek
The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

29. Siblings at Work

Siblings at Work
Amelia is back on Grey's Anatomy. And she's working here with Derek.

30. Meredith and Derek Moment - Grey's Anatomy

Meredith and Derek Moment - Grey's Anatomy
This is a nice Meredith and Derek moment, isn't it? Some Grey's Anatomy fans say we don't see enough of these anymore.

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was, Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just, it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It, I spooked you. Don't be spooked.