Rebecca Romijn started off as a model for the swimsuit issues of Sports Illustrated and for Victoria's Secret, but then moved into acting in 2000 as Mystique in X-Men. Shen then she has reprised that role twice and starred as the leading role in Femme Fatale. On television, Rebecca starred in the leading role in the short-lived Pepper Dennis on The WB.
She has made her return to television on Ugly Betty as Alexis Meade. However, she is now a recurring character and in the episode "Betty Suarez Land" she left the country in the episode. Romijn credits leaving due to disagreements with the writing of where her character is going. The actress being pregnant and playing a transgender probably didn't help either.
In 2019, Romijn appeared on Star Trek: Discovery Season 2 as Una Chin-Riley, better known as Number One, the first officer on the USS Enterprise under the command of Captain Christopher Pike. In 2022, she reprised the role on Star Trek: Strange New Worlds.