Entertainment Weekly doesn't have that problem. In fact, they are holding a poll of funniest lines uttered on TV between the dates of November 20-27, and a memorable one-liner from a recent episode of Grey's Anatomy is in the running.
Fans certainly recall when, on Thanksgiving's "From a Whisper to a Scream," Dr. Burke was first greeted by visiting Seattle Presbyterian surgeon - and medical school rival - Dr. Erica Hahn:
"So how have you been, Preston? Last time I saw you, you stole my patient's heart. Then you got shot. Karma rocks."
Dr. Hahn (played by Brooke Smith) definitely got Burke good with that one. Though his reply about enjoying her visits, but not as much as when she leaves was pretty good, too. Really, Grey's Anatomy could occupy all the spots on this list - not to take away from the other shows, of course.
Others lines in the competition came from Medium, Studio 60, The Soup, Ugly Betty, The Simpsons and House. You can VOTE HERE.