Although, she admits, things have certainly changed with the departure of cast members Kate Walsh and Isaiah Washington.
"It does feel different," Pompeo said at the pre-Emmy party for Los Angeles Confidential magazine, which she's hosting.
"I love change. I think when one door opens or closes, another one opens. The seasons change and everything changes and I think change is good."
"It's good to turn over the dirt," she continued. "It feels nice and there's new beginnings for everybody and it feels great."
Kate Walsh now has her own spin-off, Private Practice, and Washington will appear on the new NBC show, Bionic Woman, during the same Wednesday, 9 p.m. time slot. Isaiah is also in talks to star in his own series for the network beginning next fall.
"They're missed, of course," Ellen Pompeo said. "But I'm also very happy and very hopeful for their new beginnings. You know, they're both taking on whole new chapters in their careers, which I think is really exciting for them. So, to sort of think about how it affects us is rather selfish. We just have to hope that their new endeavors are as successful, and I just wish them the best."
Ellen Pompeo's feelings were seconded by her friend and Grey's Emmy-nominated co-star, T.R. Knight.
"It's been going really well," he said Sunday at a party celebrating the Emmy nominated TV producers, including Grey's creator Shonda Rhimes.
Though T.R. Knight said he's excited to be working new cast member Chyler Leigh, he is missing his pal Kate Walsh.
"I just went to her wedding this weekend, and so luckily, we'll still see her, but what she brought to the show and on the set with her sense of humor, we will miss her a lot," T.R. Knight said.
Ellen Pompeo was joined at the L.A. Confidential party by her fiancé, music producer Chris Ivery. The actress said she and Ivery aren't in the midst of any wedding plans, and don't expect to have a traditional ceremony.
"To me a wedding is a piece of paper," she said.
"I don't think it's going to change how we feel about each other. Every day is like a wedding when I wake up next to him. We just have something so special. I don't need a big dress or 400 there to declare my love. I think we declare it every day to each other. So that's just our way. Different for different people."