Katherine Heigl, T.R. Knight Preview the Premiere

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After quite a season finale, Grey's Anatomy returns tonight.

To recap where we left off in May, Cristina (Sandra Oh) was left at the altar by Dr. Burke. Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) sort of broke up, and George (T.R. Knight) found out he failed his intern exams.

"He's repeating his intern year," T.R. Knight tells Entertainment Tonight on set of the hit medical series, referring to his troubled character.

"His options were to walk away, or to repeat it, so, he's a repeater. He's made a lot of mistakes and that was one of them. You know the adultery and all that, so he needs to work out some stuff."

And part of working out that stuff means he has to figure out whether he wants to stay married to Callie (Sara Ramirez), or pursue friend Izzie (Katherine Heigl).

Justin, Katie, T.R.

While neither T.R. Knight nor Katherine Heigl would reveal the future of "Gizzie," they did talk about their romantic kissing scene - not!

"When we were kissing, I was chewing that gum," T.R. recalled, laughing.

"They have this apple gum on the camera cart," Katherine added.

"It's apple flavored, but, literally, to me, it smells like vomit... like that taste in your mouth before you are going to throw up. So, the fact that I had to kiss him, and he had that gum in his mouth, was really throwing me off, because all I was thinking of was throwing up."

Well, that's hot! The season premiere of Grey's Anatomy, "A Change is Gonna Come," airing tonight at 9 p.m. on ABC, is different this year.

The title is appropriate. With the exception of George, the rest of the gang - Meredith, Cristina, Izzie and Alex (Justin Chambers) - are now residents.

"We have just a tiny modicum of power now, but not like Bailey (Chandra Wilson) and not like Callie who is the chief resident. We have our own interns - a group of young, eager students... basically who we were two years ago," Katherine Heigl said.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.


Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.