Katherine Heigl, T.R. Knight Preview the Premiere

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After quite a season finale, Grey's Anatomy returns tonight.

To recap where we left off in May, Cristina (Sandra Oh) was left at the altar by Dr. Burke. Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) sort of broke up, and George (T.R. Knight) found out he failed his intern exams.

"He's repeating his intern year," T.R. Knight tells Entertainment Tonight on set of the hit medical series, referring to his troubled character.

"His options were to walk away, or to repeat it, so, he's a repeater. He's made a lot of mistakes and that was one of them. You know the adultery and all that, so he needs to work out some stuff."

And part of working out that stuff means he has to figure out whether he wants to stay married to Callie (Sara Ramirez), or pursue friend Izzie (Katherine Heigl).

Justin, Katie, T.R.

While neither T.R. Knight nor Katherine Heigl would reveal the future of "Gizzie," they did talk about their romantic kissing scene - not!

"When we were kissing, I was chewing that gum," T.R. recalled, laughing.

"They have this apple gum on the camera cart," Katherine added.

"It's apple flavored, but, literally, to me, it smells like vomit... like that taste in your mouth before you are going to throw up. So, the fact that I had to kiss him, and he had that gum in his mouth, was really throwing me off, because all I was thinking of was throwing up."

Well, that's hot! The season premiere of Grey's Anatomy, "A Change is Gonna Come," airing tonight at 9 p.m. on ABC, is different this year.

The title is appropriate. With the exception of George, the rest of the gang - Meredith, Cristina, Izzie and Alex (Justin Chambers) - are now residents.

"We have just a tiny modicum of power now, but not like Bailey (Chandra Wilson) and not like Callie who is the chief resident. We have our own interns - a group of young, eager students... basically who we were two years ago," Katherine Heigl said.

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I agree with HoldTheElevator.

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his name was denny and they were the PERFECT match for eachother but then he died... and now i am definitely a bigger fan of george and izzie than george and callie!

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George and Izzie?! I mean, C'mon?! Who believes that one? Izzie's PERFECT match was Dan, was that his name? Izzie's boyfriend last season. I loved him for Izzie, but I don't like George for Izzie. George is perfect for the girl he is dating right now. Why did you kill Dan? He was adorable.
I love George, don't get me wrong, I just don't like Izzie and George together, that's all. :)

Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Doesn't matter how tough we are, trauma always leaves a scar. It follows us home, it changes our lives, trauma messes everybody up, but maybe that's the point. All the pain and the fear and the crap. Maybe going through all of that is what keeps us moving forward. It's what pushes us. Maybe we have to get a little messed up, before we can step up.

Alex (narrating)