Nothing groundbreaking here, but because E! Online has complied a list of all the Grey's Anatomy cast comings, goings and other issues all in one place, we are passing it along so you know who's in, out and up in the air as Season Six gets closer by the day.

Who's returning as a regular?

These Grey's Anatomy cast members will be back as series regulars with no complications: Justin Chambers as Dr. Alex Karev, Eric Dane as Dr. Mark Sloan, Patrick Dempsey as Dr. Derek Shepherd, Kevin McKidd as Dr. Owen Hunt, Sandra Oh as Dr. Cristina Yang, James Pickens Jr. as Dr. Richard Webber, Sara Ramirez as Dr. Callie Torres and Chandra Wilson as Dr. Miranda Bailey.

What about Katherine Heigl?

Despite some backstage rumors you may have heard about, you just don't let go of an Emmy-winning movie star like Katherine Heigl, and thank goodness too.

Heigl did a hell of job with Izzie Stevens' cancer storyline last spring. Look for her to appear regularly in Season Six, although perhaps not quite as front and center as last year.

It's hard to top cancer!

P.S.: Commitment-phobic Alex got married to Izzie in the 100th episode last spring. Wonder if that's still copacetic, or if he'll have some adjustment issues?

What's up with the moms?

Ellen Pompeo is due to have her first baby in the fall. No official word yet on what her maternity leave will mean for Dr. Meredith Grey on the show, but there is talk that the actress may be able to appear in all Season Six episodes thanks to creative scheduling.

The adorable Chyler Leigh should be back on the show full-time as Dr. Lexie Grey after having her third child in May. Yes, third kid. She is not even 30!

Who's new full-time?

Remember when Brooke Smith appeared as Dr. Erica Hahn? Seems like a generation ago. She's been replaced by Jessica Capshaw as Dr. Arizona Robbins. Supercute baby doctor Robbins is confirmed to be joining the show as a regular character for Season Six.

Who's out?

Last but not least, T.R. Knight has departed the show.

The specifics of George O'Malley's departure remain unconfirmed and shrouded in mystery until you we see the premiere on September 24, but our best guess is that the bus accident was his demise and Season Six opens with a funeral for the good man.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.