Grey's Anatomy Spoilers: Trouble For Lexie and Mark

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Is trouble on the horizon for Mark and Lexie on Grey's Anatomy? You knew there had to be. Here's what executive producer Krista Vernoff tells TV Guide about that couple ...

Q: Do you have any Mark/Lexie scoop for Season 6 of Grey's Anatomy? Love them!

A: I know you won't believe it, but they're going to have problems. "They've got some obstacles for sure, but some of our more emotional moments have come from them," Grey's Anatomy executive producer Krista Vernoff reports.

That doesn't mean the coupling won't survive, however.

"We've done a lot of stories about people coming together, and now we have an opportunity to tell stories about people who are together," Vernoff says.

Now that's something we doubt people can argue with.

Sending a Signal

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

[narrating] "At the end of the day, when it comes down to it, all we really want is to be close to somebody. So this thing where we all keep our distance and pretend not to care about each other, it's usually a load of bull. So we pick and choose who we want to remain close to, and once we've chosen those people, we tend to stick close by. No matter how much we hurt them. The people that are still with you at the end of the day, those are the ones worth keeping. And sure, sometimes close can be too close. But sometimes, that invasion of personal space, it can be exactly what you need."

MEREDITH

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)