As House fans know by now, the countdown to Jennifer Morrison's exit from the series is on.

The actress will make her final appearance as Cameron on November 16.

A week later, according to a House source that spoke to Michael Ausiello, Chase reacts to the departure of his wife... by punching out House!

“Chase is very clearly off his game and struggling with the loss of Cameron," the insider said.

What prompts the throwdown? House unfavorably compares Chase to his wife, causing the accented doctor to blow his top and deck the boss.

Hey, it could be worse for House: Chase could give him the wrong medicine and kill him. Viewers know much he enjoys doing that!

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.