Fans of Mark and Lexie may want to be sitting down before reading this.

Holley Fain, who once guest starred on Gossip Girl as the manipulative wife of Nate's cousin Trip, is coming to Grey's Anatomy this season - and she'll be romancing Mark Sloan.

She'll be a "recurring love interest" for McSteamy, according to TV Line.

Fain’s character, who debuts in mid-November, works as an ophthalmologist at another Seattle-area hospital. Her boss there will be played by Ernie Hudson of Ghostbusters fame.

She should certainly shake things up at SGMWH. In addition to Gossip Girl, Fain's credits also include stints on The Good Wife, Memphis Beat and Law & Order: Criminal Intent.

Are you excited Mark is potentially getting a girlfriend? Tell us in the comments below.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.