The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.
Fringe tried to keep Peter and Olivia apart by introducing Fauxlivia from another world, but absolutely nothing could tear these two apart, not even an alternate version of Olivia. Vulnerable Olivia and stolen Peter met as children and formed a bond that transcended time and space. They literally turned back time to save each other and their family. Can there be a greater love?
Veronica Mars reminds us that epic love never dies, even when a series ends. Veronica and Logan didn't make it the first time but no Piz was going to come between the steamy chemistry that nearly explodes every time these two are on screen. They get their happy ending.
Of Lost's couple Damon Lindelhof said, "Juliet will always be Sawyer's true love." That says a lot, but finding each other before a candy machine in what might have been purgatory was one of the most emotional scenes ever shown. No quips from Sawyer with Juliet, just love.
The original skeptic and believer duo to cross over and find love were Scully and Mulder on X-Files. Even being abducted by aliens didn't destroy the love that grew out of their ultimate trust as partners and friends.
Damon returned to Mystic Falls with the intent of bringing back Katherine, but instead he found Elena, the same beauty with all of the good qualities he sought in love. Their chemistry is smoking hot and they forgive each other above all else. Damon has humanity and Elena feels free when they're together. That's magical.
Coach and Tami Taylor had, quite simply, the marriage everyone aspires to have -- full of love, affection, honesty and passion for each other with a willingness to compromise and support each other. Swoon!
She was the popular girl. He was the nerd. Their love seemed like a flower that would never blossom, until Summer learned what other OC fans discovered on Day One: Seth is The Man! Highlighted by a Spider-Man-like kiss in the rain, this relationship ended in a beautiful series finale marriage.
On Gilmore Girls Luke and Lorelai started out as friends and took a slow burn toward romance. They never lost their ability to push each others buttons to keep things fresh and we still don't know if they ended up together forever.
The ultimate back-and-forth couple... who we all knew would end up forth in the end. But it took a baby and many other boyfriends and girlfriends in between before Ross and Rachel arrived at that same conclusion on Friends. Just never use the word "break" around these two.
My So Called Life was almost as brief as any time these two spent together. The show's cancellation forever scarred girls who, like Angela, set their sites on the cool guy just out of touch. Angela got close enough to kiss Jordan, but we'll never know what could have been. Epic.