Derek and Richard do everything they can to save the life of this patient. That's what makes them the best.

In this scene from "The Becoming," Meredith and Derek talk to the parents of their patients in their clinical trial.

All of them talented, only one of them McDreamy.

That's what their marriage looks like at times.

Dr. Shepherd and Mrs. Dr. Shepherd.

It's a three-person job for Derek, Lexie and Cristina in "Here Comes the Flood," the third episode from Season Five of Grey's Anatomy. We can't wait for this awesome episode!

A final taste of JuJu

Lexie Grey. Meredith Grey. Face-off. What will transpire as the two sisters must work together at Seattle Grace?

Derek lays one on Addy.

This is awkward

Derek converses with Seattle Grace's newest visitor.

That's what every fan wants to say to this girl in the bar.