Meredith and Derek in a photo from the Grey's Anatomy Season 9 premiere. So sweet.

This is a nice Meredith and Derek moment, isn't it? Some Grey's Anatomy fans say we don't see enough of these anymore.

It's Derek vs. Meredith! These two did not end Grey's Anatomy Season 10 on a positive note.

Meredith and Derek share a sexy moment in "Here Comes the Flood," the third episode from Season 5 of Grey's Anatomy. We can't wait to see their relationship evolve and grow.

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Does it get any sweeter than this? Derek holds his child as Meredith looks on.

Patrick Dempsey as Derek Shepherd on Grey's Anatomy, in his new role as an instructor. How do you think he'll handle it?

So handsome, always. Derek Shepherd is a very good looking man, and nothing in "Here Comes the Flood," from the fifth season of Grey's Anatomy, goes against that truth.

Derek proposed to Meredith in the elevator. Appropriate, romantic and just about perfect.

Derek Shepherd, seen here in "Here Comes the Flood," the third episode from Season Five of Grey's Anatomy, is the man. Any questions? Didn't think so!

Derek looks on in this scene from Grey's Anatomy Season 11. It's from the episode "Can We Start Again Please?"

Meredith and Derek in a photo from "Shock to the System." We have a hunch this is going to be an emotional episode.