Awww, look at this happy family! Meredith walks around with her kids in this scene from Grey's Anatomy.

Meredith deals with a young patient in this scene from Grey's Anatomy. It's from "Mama Only Knows," Episode 4 of Season 11.

Meredith Grey in the Season 9 premiere of Grey's Anatomy.

Her face says it all. The loss of her husband is sinking in for Meredith Grey.

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Meredith has a lot to deal with on the Grey's Season 11 premiere. Notice she's without Derek in all these photos.

This situation looks dire. Meredith is tending to a patient on the Season 11 premiere.

Does it get any sweeter than this? Derek holds his child as Meredith looks on.

Meredith Grey in the Season 9 premiere of Grey's Anatomy.

Meredith shares a drink and a laugh with Meredith in this Grey's Anatomy scene. It's from the episode "Bend & Break."

A little help here, please? Meredith looks frazzled in this Grey's Anatomy premiere photo.

Meredith stares down an off-camera Amelia in this Grey's Anatomy scene. The latter is angry over how Meredith's handled Derek's death.