A little help here, please? Meredith looks frazzled in this Grey's Anatomy premiere photo.

It's Derek vs. Meredith! These two did not end Grey's Anatomy Season 10 on a positive note.

Meredith waves goodbye in this Grey's Anatomy scene. Her person is now gone.

Meredith smiles here at Amelia. It's a scene from the Grey's Anatomy episode "We Are Never Getting Back Together."

Wait... huh? Who?!? What?!? Derek and Meredith are a tad taken aback in this Grey's Anatomy scene.

It's nearly time to say goodbye to Cristina on Grey's Anatomy. This is a scene from the episode "Change of Heart."

This is one of the cutest photos ever of Mer and Der. It is from the Grey's Anatomy episode "Change of Heart."

Has their argument actually continued into the operating room? That just can't be good for anyone.

Whatever their conversation was about, Meredith doesn't appear thrilled with the outcome.

With the stress of dealing with both work and home, Derek and Meredith look to be struggling to keep it together.

Congrats to Cristina! She's been nominated for a Harper Avery!

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.