In the season finale of Gossip Girl, entitled "Much I Do About Nothing," Dan and Serena slow-dance... and possibly make up? We can hope!

In this photo from "All About My Brother," from the first season of Gossip Girl, Blair and Serena talk on the steps. They have had their problems, these two - but when you compare it to Blair's other friends (and we use the term loosely), Serena is a saint!

Blair Waldorf and Serena van der Woodsen in the first episode of the third season of Gossip Girl. We love these two as best friends!

Blair and Serena may fight a lot, but these two will be close until the bitter end. It's one of the nice things about Gossip Girl.

A beaming Serena presumably receives good news via text message in this photo from "Remains of the J."

So ... you know what Nate's thinking here! He's had both, why not combine ... just kidding. Maybe. It's Nate. You never know.

Serena van der Woodsen is a scandalous New York socialite ... or so we are led to believe.

Eric's boyfriend Jonathan hacked Gossip Girl in the season finale. Did not see that coming.

Stars Blair Waldorf (Leighton Meester) and Serena van der Woodsen (Blake Lively) film a scene for Gossip Girl in New York. Looks as though they are listening to a phone message ...

Serena and Blair in "The Wrath of Con," the episode of Gossip Girl originally airing May 4, 2009.

In "The Serena Also Rises" from the second season of Gossip Girl, it's a day of mother and daughter bonding for Serena and Lily van der Woodsen. Talk about a couple of beauties.

A nice picture of Blair, Chuck and Serena all dressed up in "The Grandfather," from the second season of Gossip Girl.