In more ways than one. Here, Patrick Dempsey is seen on the set of "Made of Honor," a new movie he's filming.

Alex, Izzie and George take orders from the Nazi.

The Season Four cast of Grey's Anatomy: Starring the lovely Ellen Pompeo (Meredith Grey), Patrick Dempsey (Derek Shepherd), Sandra Oh (Cristina Yang), Katherine Heigl (Izzie Stevens), T.R. Knight (George O’Malley), Justin Chambers (Alex Karev), Chandra Wilson (Miranda Bailey), James Pickens, Jr. (Richard Webber), Sara Ramirez (Callie Torres), Eric Dane (Mark Sloan) and Chyler Leigh (Lexie Grey).

Will Callie be tempted to change teams again? This is Grey's Anatomy. Would anything shock you?

Izzie fake-codes to get Meredith out of the bathroom, but she's really feeling the impact of chemo pretty hard.

No one dies on this man's watch!

Justin Chambers and his wife, Keisha, along with Kate Walsh and her fiance, Alex Young, at the Chrysalis Butterfly Ball, an event hosted by Grey's Anatomy co-star Eric Dane and his actress wife, the beautiful Rebecca Gayheart.

Addison calls him out on his crap!

Patrick Dempsey looks great from any angle.

McDreamy and the real-life Mrs. McDreamy.

Mrs. Dr. McDreamy treats the Webbers' nice, Camille Travis.

Patrick Dempsey, who has gone on to great things, most notably Grey's Anatomy.