Really, Penny?!? Amy has the question you'd expect her to have in this scene from the season five premiere.
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Raj hands Howard something during the game night with Sheldon and Leonard.
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Wolowitz talks to a beautiful girl named Mikayla (Jodi Lyn O'Keefe)... that turns out to be a hooker. Does that bother Wolowitz? Since Leonard and Raj paid... not at all!
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Howard and Leonard must get a pigeon out of the clean room at the University on The Big Bang Theory.
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Penny meets Raj and Wolowitz in the pilot episode of The Big Bang Theory. Wolowitz will begin his lifetime of sleazily hitting on her while Wolowitz is unable to talk to her.
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Leonard and Sheldon meet Dennis Kim, a 15 year old childhood prodigy that makes them question their intelligence, especially Sheldon.
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Poor Penny attempts to go bowling as Raj and Wolowitz watch on and drool.
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Sheldon and Mrs. Hofstadter (Christine Baranski) decided to perform a little duet in Rock Band to some Journey. Watching them sing and dance was priceless.
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TBBT Quotes

Penny, there's only one cookie with something in the middle that solves life's problems, and that's an Oreo. Or a Nutter Butter, if you're in a pinch.

Sheldon

Penny: Here's a question-- as an alien pretending to be human, are you planning to engage in any post-prom mating rituals with Amy?
Sheldon: There are post-prom mating rituals?
Penny: Not always. Unless your date drives a van with an air mattress, then always.
Sheldon: Well, if it's part of the prom experience, then I'm open to it.
Penny: You're kidding.
Sheldon: I may be an alien, but I have urges.If Amy wants to copulate by firing her eggs into space, well, then, I will happily catch them with the reproductive sac on my upper flermin. I'm not the best at reading facial cues, but I can see that you're a little turned on.