Amy has a request of Sheldon on the episode "The Desperation Emanation." She wants to introduce him to her mother.
Added:
That's Katee Sackhoff and that's George Takei. Both guest star as themselves on the episode "The Hot Troll Deviation."
Added:
Who needs human companionship?!? Not Sheldon, this character hopes, on the episode titled "The Zazzy Substitution."
Added:
How can Sheldon live longer? That's what he tries to figure out on the episode "The Cruciferous Vegetable Amplification."
Added:
Say hello to Sheldon's nemesis on The Big Bang Theory: oh, yes, it's Evil Wil Wheaton!
Added:
The Big Bang Theory airs on a new night during its fourth season. But this poster promises the same old hilarity.
Added:
Sheldon requires a chaperon on his first date when season four of The Big Bang Theory kicks off. Penny is chosen for the job.
Added:
Sheldon has a request for Penny on the fourth season premiere of The Big Bang Theory. Will she tag along on a date with him?
Added:
Science pays off for Wolowitz on the season four premiere. He gets some solid use out of his robotic arm.
Added:
Jim Parsons is seen here at The Big Bang Theory Comic-Con panel in 2010. He and his castmates dished on the new season at the event.
Added:
A flashback to when Leonard first moved in with Sheldon and they signed the roommate agreement.
Added:
Before there was Leonard, there was an even angrier roommate. Angry enough to write "Die Sheldon Die."
Added:

TBBT Quotes

I just gave you my virginity, woman. Cool your jets!

Sheldon

(Singing) Thor and Dr Jones, Thor and Dr. Jones. One plays with lightening, the other plays with bones.

Howard and Raj