Leonard tries to keep an affair secret from Sheldon on "The Irish Pub Formulation." This is a scene from that episode.
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Amy has a request of Sheldon on the episode "The Desperation Emanation." She wants to introduce him to her mother.
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That's Katee Sackhoff and that's George Takei. Both guest star as themselves on the episode "The Hot Troll Deviation."
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Who needs human companionship?!? Not Sheldon, this character hopes, on the episode titled "The Zazzy Substitution."
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How can Sheldon live longer? That's what he tries to figure out on the episode "The Cruciferous Vegetable Amplification."
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Sheldon requires a chaperon on his first date when season four of The Big Bang Theory kicks off. Penny is chosen for the job.
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Sheldon has a request for Penny on the fourth season premiere of The Big Bang Theory. Will she tag along on a date with him?
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Science pays off for Wolowitz on the season four premiere. He gets some solid use out of his robotic arm.
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The Big Bang Theory Season 4 Quotes

Penny: Hey, Sheldon, did you change your Wi-Fi password again?
Sheldon: Yes, it's "Penny, get your own Wi-Fi." No spaces.

Raj: Well, to paraphrase Shakespeare: It's better to have loved and lost than to stay home every night and download increasingly shameful pornography.
Penny: Oh... you poor baby.
Raj: What's wrong with me, Penny?
Penny: Nothing, nothing. You know, if we weren't friends - and you hadn't brought up that creepy pornography story - I'd be on you like the speed of light squared on matter to make energy.
Raj: Hey, you totally got that right. E = MC squared.
Penny: I listen. I have no idea what it means, but I listen.