Amy: Jewelry? Seriously? Sheldon, you are the most shallow, self-centered person I have ever met. Do you really think that another transparently manipul... Oh! It's a tiara! A tiara. I have a tiara! Put it on me, put it on me, put it on me, put it on me, put it on me, put it on me, put it on me.
Penny: You look beautiful
Amy: Of course I do. I'm a princess and this is my tiara.
Sheldon: You were right, the tiara was too much.

Amy: When you told me I was going to be "losing my virginity," I didn't think you meant you'd be showing me Raiders of the Lost Ark for the first time.
Sheldon: My apologies. I chose my words poorly. I should have said you were about to have your world rocked on my couch.

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?
Penny: Damn.
Amy: Well, at least, when we do make love, Sheldon won't be thinking about his mother.

You think that's bad. In college, I passed out at a frat party and woke up with more clothes on.

Sheldon: No, go ahead, say it. I know what it is. I've heard it my whole life. The word's "annoying." Go ahead, say it. Say it. Say I'm annoying.
Amy: Sheldon...
Sheldon: Oh, it won't hurt my feelings. Go ahead, Amy, say I'm annoying. I'm annoying. I'm annoying. I'm annoying.

Leonard: What are you doing?
Amy: We're playing doctor. Star Trek style.
Sheldon: I'm in hell, Leonard. Don't stop.

Go away Sheldon is nibbling on my ... 14. Yes!

I obviously have the flu, coupled with sudden on-set Tourette's Syndrome.

Amy: This year's donations may go to, say, the geology department.
Sheldon: Oh dear, not the dirt people.

You were right. I had nothing to worry about. That skank's your problem, not mine.

Amy: Oh ... are we nervous, Dr. Cooper?
Sheldon: No. What you see is a man trembling with confidence.

Amy: Goodnight, Painting Penny. Goodnight, Real Penny.
Penny: Goodnight, Real Amy.
Amy: You don't have to say goodnight to Painting Amy, because she's never leaving. Bernadette: Goodnight, Real Penny. Goodnight, Transvestite Penny.

TBBT Quotes

I was expecting applause but I suppose stunned silence is equally appropriate.

Sheldon

Sheldon: Nothing more fun than a paradigm shifting evening of science.
Penny: (to Leonard) And you thought it was soaping me up in the shower.