ADDISON: "What is this?"
MARK: "Lunch. Want my pickle?"

MARK: "Seen what's-his-face?"
IZZIE: "Alex Karev?"
MARK: "Poor bastard seems to get a thrill out of tagging along after me."
MEREDITH: "He's camping."
MARK: "In that case, how would you like to get a thrill out of tagging along after me?"

"Derek's damaged goods. I know because I'm the one that damaged him. But ask yourself, do you really want to drink out of a poisoned well?"

"Start over, Meredith. Start fresh."

MEREDITH: "Number one: No flirting. Second: No talking about Derek and C: No giving me the face."
MARK: "The face?"
MEREDITH: "The McSteamy face. Doesn't work on me. I'm immune."
MARK: "If I'd gone off to the woods, I would've invited you to keep me warm."
MEREDITH: "Breaking rules 1, 2 and 3."

MEREDITH: "Okay, before you start, there are rules to this friendship thing, or whatever."
MARK: "The Dirty Mistresses Club has rules? Gosh, I didn't think a bunch of dirty mistresses would be a little less uptight about these, uh, rules."

MARK: "Nancy-pants?"
NANCY: [smiles] "Hey loser."
MARK: "I wish Derek told me you were coming to visit."
NANCY: "Oh, like he tells you anything these days."
MARK: "I'm working on that."
NANCY: "What are you doing here, Mark? Are you trying to torture him?"
MARK: "He's my family, Nancy. Plus I needed a change of pace.... Plus I slept with my tennis partner's wife and he bought a gun."
NANCY: "There it is!"

MARK: "So we're clear: You knew when you stepped into that surgery you forfeited your future in plastics, right?"
ALEX: "But, Dr. Sloan-"
MARK: "Give me my phone back."

MARK: "At least now you don't have to feel guilty anymore."
ADDISON: "Shut up."

MARK: "She told you. I've known you my whole life, I grew up with you so I know what you're thinking. That there is a year of your life wasted. Trying to make it work with Addison and you could have been with Meredith. That you could be happy right now. That all of this, everything... that you and Meredith could have had a real chance. Still, I thought you should know the truth. I thought I owed you that, as a friend."
DEREK: [walks away] "You're not my friend."

MARK: "Is that your boyfriend again?"
CALLIE: "I do not have a boyfriend."
MARK: "Then why the guilty face?"
CALLIE: "You were sexier when you weren't talking."

MARK: "Can I buy you a drink, Dr. Torres?"
CALLIE: [gets up] "Not unless you have it delivered to my hotel room... I'm going to bed. You coming?"

Grey's Anatomy Quotes

COOPER: "It's wrong?"
NAOMI: "You need to meet a grown up. You need to date someone your own age."
VIOLET: "Someone without a porny internet name and perhaps no criminal past."
NAOMI: "A nice girl."
VIOLET: "A reliable girl."
NAOMI: "Someone who you can have a relationship with."
VIOLET: "You’re a respected doctor."
NAOMI: "Go out in the real world. Meet a woman your own age and go out."
VIOLET: "Be a man."

ADDISON: "You work with your ex-husband in a shrine for your ex-husband."
NAOMI: "It’s actually a good book. And we're friends. And we stayed friends after we divorced. It’s very healthy. We're healthy."
ADDISON: "What happened between you and Sam?"
NAOMI: "Addison, you and I were close in med school, but it was a long time ago."
ADDISON: "Oh, Naomi. Come on. You can’t stay mad at me forever. I know you."