Chuck struggles with his cover love life and his real one when he meets Lou (Rachel Bilson) who actually seems interested in him. Meanwhile, his cover relationship with Sarah heats up when they go on a double date with Ellie and Devon and try to explain their sex life. Meanwhile, a poison specialist (Kevin Weisman) is trying to obtain ocdes to a nuclear facility and is using a truth serum to get what he wants. After everyone is exposed to the truth serum, Chuck learns the truth about his partners.
Sarah [about the antidote]: Chuck, take it!
Chuck: What? No way, I'm not gonna take it knowing Ellie's been poisoned, and you guys!
Sarah: I'm sorry Chuck, there's no debating this. It has to be you!
Casey: Right now, or I'll force it down your throat!
Chuck: Alright. I'm going to pretend to take it then run to my sister and make her take it. Why the hell did I just say that out loud?!
Sarah: It's the poison, it makes you tell the truth!
Casey: If you do that, I'll chase you, put a gun to your head and threaten to pull the trigger!
Chuck: Would you really shoot me?
Chuck: Yeah, why waste a bullet? We're already dead!
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Sarah: I'm so sorry, Chuck.
Chuck: Hey, I've lived a good life. Who else can say they flew a helicopter or saved the lives of innocent people?
Casey: Courageous and honorable members of the U.S. military
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