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It's Always Sunny in Philadelphia Season 1 Episode 4: "Charlie Has Cancer"
After discovering he might have cancer, Mac and Dennis try to find a girl to sleep with Charlie; Mac ends up falling for a transsexual, Carmen; Dee gets Dennis to hire an actress friend to help out at the bar.
Mac: Is that a penis in your pants? Carmen: Yeah. Mac: You lied to me. Carmen: No, I didn't. You lied to me. You don't workout? Please! I've seen you at the gym. You're ripped. Mac: No, don't turn this around -- wait, really? You think so?