David Anders has landed another high-profile guest-starring gig.

The actor - who has appeared on The Vampire Diaries, Warehouse 13, 24 and can currently be seen on Once Upon a Time - has signed on for a pivotal House role.

According to TV Line, Anders will take part in the same episode that brings Jeffrey Wright to Princeton Plainsboro, portraying the Patient of the Week (Audrey Marie Anderson will play his wife), but not just any Patient of the Week.

“David’s presence will change the course of the season,” says producer Greg Yaitanes. “We are all fans of his work here at House and excited he is lending his talent to such a significant episode of our series.”