On Grey's Anatomy Season 10 Episode 22, Isaiah Washington made his return to Seattle as Preston Burke.
And this unexpected reprisal got us thinking about whether or not Addison Montgomery may ever make her way back. Or even Izzie Stevens.
Indeed, possibly more than any series that has found such success, Grey's Anatomy has lost a number of key cast members over the years.
What are the stars behind these beloved characters up to these days? We're so glad you asked! Take a look below: