What does the future hold for Meredith Grey and Derek Shepherd? Hopefully, only love. But we know it's never easy.

Lexie Grey. Meredith Grey. Face-off. What will transpire as the two sisters must work together at Seattle Grace?

Derek Shepherd is still one who can make heads snap with his good looks. And fix heads with his mad skillz as a brain surgeon! What a combination.

The wear and tear of life at Seattle Grace has done little to diminish the sexiness of Derek "McDreamy" Shepherd. Nor do we expect it to.

Meredith is none too thrilled about the new girl Derek met at the bar. The fact that it's her sister can't help matters, either.

The Season Four cast of Grey's Anatomy: Starring the lovely Ellen Pompeo (Meredith Grey), Patrick Dempsey (Derek Shepherd), Sandra Oh (Cristina Yang), Katherine Heigl (Izzie Stevens), T.R. Knight (George O’Malley), Justin Chambers (Alex Karev), Chandra Wilson (Miranda Bailey), James Pickens, Jr. (Richard Webber), Sara Ramirez (Callie Torres), Eric Dane (Mark Sloan) and Chyler Leigh (Lexie Grey).

Derek Shepherd proved to be Richard's choice for Chief, and also a good friend to Preston.

Derek Shepherd will serve as Preston Burke's best man. But they're both the best in our book.

That's what every fan wants to say to this girl in the bar.

It's been better lately. But can it sustain?

Cristina and Derek discuss the events of the day.

Derek, Preston and Cristina do what they do best.