In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," guest star Bernadette Peters is sandwiched between ex-spouses George (TR Knight) and Callie (Sara Ramirez).

In this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy, Izzie is trying to get what she wants. Using food.

In this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy, Lexie and George continue to bond. Do you like them as a couple?

In this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy, Izzie and George seem to be getting back on track. As friends. Their whole post-marriage hookup thing fizzled out.

In this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy, it looks like Izzie and George are back to being good friends again. That is probably for the best!

George gets to retake his intern exam in this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy. But will it be completed, given the certain plumbing problem?

George O'Malley retakes his intern exam in this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy.

The flood is coming. Or at least the plumbing nightmare. George feels a drip and looks upwards in this picture from "Here Comes the Flood," from the fifth season of Grey's Anatomy.

In a photo from "Brave New World," from Season 5, Richard gives George one of his usual talkings to. Wonder what about?

Cristina and George look on in a photo from "Brave New World" from Season Five of Grey's Anatomy.

Dr. George O'Malley is back and better than ever in a photo from "Brave New World" from Season Five of Grey's Anatomy. Eh, he's just George, but that's why we love him.

George talks to Meredith and Izzie in a photo from "Brave New World" from Season Five of Grey's Anatomy. He has slept with both of them! Amazing.