George and Izzie smile at each other in a photo from "Brave New World" from Season Five of Grey's Anatomy. These two used to be best friends, then hooked up, then broke up. What next?

George and Izzie look a little tipsy in a photo from "Brave New World" from Season Five of Grey's Anatomy. Good to see them hanging out again!

George O'Malley is now a resident at long last! How will he respond now that he has interns? Here's our guy in this photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy.

Well, not that kind of action. But there's a lot of activity in this photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy, as the residents discuss their respective days.

A picture of Lexie and George, talking things out. Do we think she still wants him after she blew up at him the last time? We'll see...

George sighting! George sighting! Will O'Malley actually have a central role in this episode? Here's hoping.

Remember Gizzie? As in George and Izzie? You can be forgiven if you don't, but here they are in a cute, recent photo.

Meredith, Cristina and George in a photo from "Elevator Love Letter."

Meredith and George (he lives!) in a promotional photo from "Elevator Love Letter."

Alex and George look upward as a patient prepares to take the plunge ... and not the kind you want to see them take.

George and Owen at the wedding of Alex and Izzie. These two make a great trauma surgeon team, as we've seen in recent weeks.

It was a sweet scene when George gave away Izzie to Alex at the wedding, when she became weak and could not walk under her own power. Tears were shed at this website.