Izzie Serious?

Is she serious? Well, maybe not. But Izzie Stevens (Emmy winner Katherine Heigl) sure is back in full force and looking forward to running the surgical show in Season Four of Grey's Anatomy.
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Smiling Sloan

Mark Sloan (Eric Dane) shows us a rare smile in an early episode of Season Four of Grey's Anatomy. Hopefully this fellow will be smiling more in this exciting new campaign.
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Cristina Hides

Cristina Yang (Sandra Oh) hides from Mrs. Burke (Diahann Carroll). But we have a hunch that it's not going to work out that easily.
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Newbies

Lexie Grey (Chyler Leigh) is a new intern at Seattle Grace. So are those other peeps, but we're most concerned with the girl threatening to break up our MerDer love.
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New Faces

There's a new gang at Seattle Grace now. How will the young surgeons we've come to know and love react to this new crew?
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Isobel is in Charge

At least Izzie Stevens is trying to convey that message. She is having a tough time on this day at Seattle Grace, however.
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Hey, You! Back!

Izzie restrains a young visitor to the hospital. She's having quite the hectic day at the office.
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LexDer?

Eh, that couple nickname just doesn't work. Neither does the chemistry between these characters. Right, fans?
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MerDer Love or Hate?

What does the future hold for Meredith Grey and Derek Shepherd? Hopefully, only love. But we know it's never easy.
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Grey vs. Grey

Lexie Grey. Meredith Grey. Face-off. What will transpire as the two sisters must work together at Seattle Grace?
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Lexie Smiles

Lexie Grey flashes a smile at Seattle Grace. Will the interns grow to love or hate this new cutie?
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Meredith Looks Distraught

Dr. Meredith Grey has a pouty, upset look on her face in this photo. We're accustomed to seeing this expression by now!
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Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith