So McHandsome

Derek Shepherd is still one who can make heads snap with his good looks. And fix heads with his mad skillz as a brain surgeon! What a combination.
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Still Sexy After All These Years

The wear and tear of life at Seattle Grace has done little to diminish the sexiness of Derek "McDreamy" Shepherd. Nor do we expect it to.
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I'm the Girl From the Bar!

Meredith is none too thrilled about the new girl Derek met at the bar. The fact that it's her sister can't help matters, either.
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Interns on the Run

Because Bailey is on the warpath? Because Mer and Der are hooking up in the on-call room and they want to watch? Who knows!
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Izzie's Bitches!

Izzie has a new group of interns following her around. We will have to see how Dr. Stevens adjusts to being the one bossing peeps around instead of in the doghouse.
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Bailey Bosses Karev

Miranda tells Alex Karev who's boss around here. As if there were any doubt about that since his first days as an intern!
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Good Friends on GA

Izzie and Alex used to be an item, but now they're just good friends. It's nice to see for fans of both characters.
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Bitter Bailey?

Rumor has it that Miranda Bailey is a little bit bitter and back to her bad-ass self in Season Four. Izzie Stevens could attest to this.
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Grey's Anatomy Season 4 Quotes

Everyday is my mothers birthday. My mother was born in March. He lied. He's a liar. And I'm glad. Really, I'm glad that you found him charming. I'm sure he was delightful. He's a blast after five drinks, not so much after nine though; he gets a little weepy and mean. He's a drunk, Meredith. He probably came in and told you how wonderful you are. How sad he is he doesn't get to spend more time with you. You know, yesterday he told me I was his favorite daughter. The day before, I was an ungrateful bitch. The week before, he wrote me a check for $20,000 because he said I deserved everything life had to offer, because he was so proud of me, a lifetime's worth of proud. So thank you for letting me know that I need to keep a better eye on him. Thanks.

Lexie

Meredith: I will take the ER and your interns.
Cristina: Are you sure?
Meredith: Take the surgery. Makes you feel better and you start to regain strength. [leaves]
Alex: I saw the whole thing, Yang. You can stop pretending.
Cristina: Oh I'm not pretending. I'm sad. I'm very sad. Me so sad!
Alex: Yes, you tried.
Cristina: Hey, forget it. Sad is mine. Go, find your own pretend-emotion.