Mark Sloan and Izzie Steves

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Izzie and Mark have a serious conversation in the halls of Seattle Grace.
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Isobel and Mark

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Mark and Izzie have a serious conversation at Seattle Grace.
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Bizarre Love Triangle?

Maybe, and not quite the way you think! Callie Torres, Erica Hahn and Mark Sloan have a conversation in "The Becoming."
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Callie Torres and Mark Sloan

Callie Torres and Mark Sloan made some love in the on-call room. But surprisingly, Mark later gave her the cold shoulder.
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Crazy Callie

In this scene from "The Becoming," from Grey's Anatomy Season Four, Callie Torres (Sara Ramirez) is looking a little forlorn and unsure of what to do.
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Passed Over

In this scene from "The Becoming," Erica Hahn reacts to having lost out on an award to Preston Burke. That guy continues to get the best of her even though he's not even on the show anymore!
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All Together Now

In this scene from "The Becoming," from Grey's Anatomy Season Four, our favorite group of interns / residents are all together. What are they looking at?
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An Expression of Concern From Derek

In this scene from "The Becoming," from Grey's Anatomy Season Four, Derek is a bit worried as he prepares for the difficult operation he knows is to come.
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Mer and Der at Work

In this scene from "The Becoming," from Grey's Anatomy Season Four, Meredith and Derek practice on a fake brain before delving into the real one later on.
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She Got Game

In this scene from "The Becoming," from Grey's Anatomy Season Four, Meredith is preparing for an surgery in her clinical trial with Derek. Girl's got skills!
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Pay Attention to Me!

In this scene from "The Becoming," from Grey's Anatomy Season 4, Meredith is preparing for an operation in her clinical trial with Derek. But she's really thinking about the brain surgeon she's working with.
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Jello?

In this scene from "The Becoming," Meredith and Derek practice on a fake brain as they prepare for an operation in their clinical trial with Derek. Cool... and gross.
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Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith