Two Concerned Doctors

In this photo from "Losing My Mind," Derek Shepherd (Patrick Dempsey) and Meredith Grey (Ellen Pompeo) wear expressions of concern as they tend to their patients. They are dealing with their own personal issues, as well.
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A Lighter Moment

In this photo from "Losing My Mind," Derek and Meredith's patient shares a lighter moment.
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Working It

In this photo from "Losing My Mind," Derek Shepherd (Patrick Dempsey) and Meredith Grey (Ellen Pompeo) work with patients... and work with each other!
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Derek the Handsome Devil

In this photo from "Losing My Mind," Derek Shepherd (Patrick Dempsey) looks as handsome as ever. He needs to get his act together and propose to Meredith!
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MerDer Love Again

In this photo from "Losing My Mind," Meredith and Derek share smiles. It's just a matter of time before they are together for good!
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Derek at Work

In this photo from "Losing My Mind," Derek Shepherd is hard at work. Maybe he needs to work a little harder with Meredith, too!
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The Becoming

In this photo from "Losing My Mind," Meredith and Derek are hard at work on their clinical trial. Will this be what brings them back together?
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Our Girl Meredith

We'll stand by you, Mer, as you get over your issues. But can you hurry it up a little?
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Mark Cracks a Smile

In this photo from "Piece of My Heart," Dr. Mark Sloan (Eric Dane) enjoys a smile at the expense of his friend Derek Shepherd, who's surrounded by all sorts of women he has complicated histories with.
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Rose the Nurse

In this photo from "Piece of My Heart," Addison looks on as Rose (Lauren Stamile) watches the floors tick by, wishing she could just get off the elevator. Fans probably want her off it as well ... and falling down the elevator shaft!
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So Good Looking

In this photo from "Piece of My Heart," Dr. Derek Shepherd (Patrick Dempsey) may be having the elevator ride from hell, but man, he's still so handsome. Love him!
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Ouch, Derek

In this photo from "Piece of My Heart," Dr. Derek Shepherd (Patrick Dempsey) looks like he wishes he never got out of bed this morning... or at least had taken the stairs.
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Grey's Anatomy Season 4 Quotes

I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie

[narrating] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or ... we get left behind.

Meredith