Is Dean taking off the handcuffs or putting them on? If anything, it’s probably to keep them safe in case she gets rebooted by the British Men of Letters and tries to kill them again.
Obviously, Dean and Toni haven’t been the best of pals. It doesn’t seem like much has changed even in their trapped situation. Snarky comments are probably flying.
Mr. Ketch may have left Sam and Dean to die in the bunker, but that doesn’t mean they will just quit. It looks like Sam is trying to find some key that will get them out.
Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.