MEREDITH: "We know he cheated on you. That's why we let you turn the house into Santa's Freaking Village. We're not big on holidays. We're trying to be supportive, because you're having a hard time. But right now, Alex is having a harder time."
IZZIE: "Why should anybody care what kind of time Alex is having!?"
MEREDITH: "Because he's Dirty Uncle Sal!"
IZZIE: [looks confused]
MEREDITH: "Dirty Uncle Sal. The one who embarrasses everyone at holidays and family reunions and who can't be left alone with the teenage girls, but you have to invite him anyway. Look... I have a mother who doesn't recognize me and as far as family goes, you guys are it. So I know you're pissed at Alex, but maybe... maybe you could try and help him anyway. Like, in the spirit of this holiday you keep shoving down everybody's throats."

MEREDITH: [to Derek] "I am a sink with an open drain, and anything you say runs straight out." [storms off]
GEORGE: "She probably could have used a better metaphor."
IZZIE: "Give her a break, she's got a hangover."

DIVORCE LAWYER PATIENT: "Any of you are looking to get out of a bad marriage?"
GEORGE & IZZIE: [smirking] "No."
DIVORCE LAWYER PATIENT: "Dr. Shepherd?"
DEREK: "Yes. No!"

IZZIE: "I'm just curious, George. Curious George! Get it? Okay, nevermind. All I'm asking is, where do you live?"
GEORGE: "Listen to this, there's an old school arcade game that's been known to enduce seizures if you reach level 53!"

IZZIE: "You're tall."
DENNY: "I know."

[to George] "Remember the good old days? When you lived with us, when you used to tell me stuff. Like... where you live?!"

MIRANDA: "Do you have a problem?"
IZZIE: "No."
MIRANDA: "Do you have a mocha latte?"
IZZIE: "No."
MIRANDA: "Then go away."

BAILEY: "Izzie, both Dr. Shepherds need an intern up on ICU."
IZZIE: "Wait... both of them, together? Me, by myself, with the two married people who hate each other?"
BAILEY: "Go. Cristina, you're on the thoracotomy."
CRISTINA: "With Burke? I can't have the hateful married couple instead?"

IZZIE: "Why do you do that?"
ALEX: "Do what?"
IZZIE: "Act like an ass whenever any one but me is around. They hate you enough as it is."

"You think... you think you know someone, know who they are. You share a house and make wishes on eyelashes with them and we don't know each other, none of us. We're just a bunch of interns who work together. There's nothing there!"

IZZIE: "How can someone be so offensive, yet so charming all at the same time?"
ALEX: "It's an art form."

ALEX: "Morning, Dr. Model."
IZZIE: "Dr. Evil Spawn."
ALEX: "Ooooh, nice tat. Do they airbrush that out for the catalogs?"
IZZIE: "I don't know. What do they do for the 666 on your skull?"

Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey